Do you still experience asthma symptoms despite treatment?


Living with asthma can be difficult. Daily activities such as going for a walk, climbing stairs, or even sleeping through the night may become difficult to manage during an asthma attack.

While there is no cure for asthma, finding the right treatment may help you feel better. Many people struggle to keep their asthma symptoms like shortness of breath, coughing, wheezing and chest tightness under control.

If you’re frustrated with your asthma symptoms, you’re not alone. Researchers are exploring new treatment options to better control asthma attacks (flare-ups).

Learn more about joining this new asthma study and get help finding a study site near you.

Participants will meet with an asthma research doctor and continue their regular asthma inhalers. AstraZeneca, the study sponsor, will provide the study medicine at no cost.

Study Overview

We’re looking for adults with asthma who experience attacks (flare-ups) to learn more about an exciting new research study!

This research is testing an inhaled experimental medicine that is designed to better control asthma symptoms.

The study will evaluate how well this investigational medicine, inhaled twice a day for 3 months, may reduce asthma attacks (flare-ups) and improve symptom control.

If you or someone you know struggles with asthma control, this study may be an opportunity to explore a new inhaled treatment option!

What is Asthma? 

Asthma is a common lung disease that causes inflammation and shrinking of the airways, leading to reduced airflow in and out of the lungs. This can result in symptoms such as coughing, wheezing and shortness of breath.

Asthma is a chronic disease that affects millions of people and their families every day. Since there is no cure for asthma, it is important to control the symptoms of the disease.

Asthma symptoms may include:

• Trouble breathing or shortness of breath
• Coughing
• Wheezing
• Chest tightness
• Trouble sleeping due to asthma

Currently, there is no cure for asthma and many people struggle to find a treatment plan that controls all of their symptoms. 

What is an exacerbation or attack (flare-up)?   

Asthma exacerbations (also known as attacks or flare-ups), happen when asthma symptoms suddenly worsen or become more frequent.  This can mean increased coughing, wheezing, shortness of breath, or chest tightness that lasts longer than usual.  

Attacks (flare-ups) vary from person to person—some may experience mild symptoms, while others may have severe breathing difficulties that require medical attention. Understanding and managing attacks (flare-ups) is key to keeping asthma under control. 

What are common asthma symptoms?

Recognizing the signs of an asthma flare-up 

  • Shortness of breath – feeling winded while doing normal activities  

  • Wheezing or coughing more than usual – especially at night or after exposure to your asthma triggers 

  • Chest tightness or pressure – like a heavy weight on your chest 

  • Changes in phlegm - more mucus or a different color than usual  

  • Frequent rescue inhaler use - needing a quick relief, more often 

  • Unusual tiredness – feeling drained even without much activity 

If these symptoms sound familiar, it might be time to explore new treatment options to better manage your asthma and prevent attacks (flare-ups).  
If you are currently having difficulty breathing, contact your doctor right away or seek urgent medical care.  

Who can join the study?

We are looking for individuals who struggle with asthma symptoms to take part in this research study.

Key qualifications:

  • 18 and 80 years old 

  • Diagnosed with asthma for at least 1 year 

  • 1+ flare-up in the past year 

  • Use a daily inhaler(s) to manage symptoms 

To enroll in the study, individuals must meet complete in-person health screening visit and meet all study qualifications.

What to expect:

  • Meet with an asthma study doctor  

  • Participate in 9 in-person clinic visits over 5 months 

  • Receive study medicine or an inactive substance (placebo) at no cost 

  • Reimbursement may be available for your time and effort 

If asthma symptoms are affecting your daily life, this study may be an opportunity to explore new treatment options! 

Take the pre-screening questionnaire.

What to expect when joining an asthma study?

The pre-screening process 

If you are considering joining a study, the first step is to learn about the study and see if you meet the initial qualifications. To see if the study is a good fit for you, you'll answer health-related questions online.

If you pass the online pre-screening questionnaire, you’ll be connected to a research site located nearest you. The research site will reach out to you directly.

Take the pre-screening questionnaire.

Getting matched to a study site

The study doctor and research team at that trial site will provide additional study information and guide you through the next steps.

Study Sites conducting the study can be found here: ClinicalTrials.gov

The screening and informed consent process 

If you meet the pre-qualifications, you’ll be invited to the study site for an in-person visit to learn more about the study.

At your appointment, the asthma research doctor and research team will explain the study in-depth, including risks and benefits. They will also answer any questions you may have.

If you are still interested in the study after speaking with the asthma research team, you will sign an informed consent document, confirming your willingness to voluntarily join the study and undergo study assessments.

Study activities will vary at each visit, but may include:

  • Health-related questionnaires  

  • Brief physical exam 

  • Breathing Tests (Spirometry) 

  • Blood, urine and nose swab sample collection 

  • Electrocardiogram (ECG) 

Frequently Asked Questions

  • Clinical research is the process of testing and developing medicines to potentially prevent, treat, or manage diseases. Before any medicine becomes available, it must undergo clinical trials to ensure safety and effectiveness.

  • This study is designed to see if an experimental medicine could potentially reduce asthma attack or flare-up symptoms and improve breathing.

  • You’ll help us learn about an experimental medicine to see if it could potentially be a new option in asthma treatment.

  • No. All study-related care is provided at no cost, and you do not need healthcare to participate. You will not have to pay for the experimental medicine, but your regular medications will not be paid for as part of the study.

  • Yes. Taking part in a study is always your choice. You can change your mind or stop taking part at any time, for any reason.

  • Here are some useful links and language to provide patients with more important information about asthma.

    Visit the American Lung Association's website for comprehensive information about asthma, including symptoms, causes, diagnosis, treatment, and management strategies 

    Asthma and Allergy Foundation of America (AAFA) - Explore the AAFA Foundation's patient resources for valuable information on asthma, including educational materials, support groups, and community resources 

  • All participant data will be kept confidential and used only for research purposes. We follow strict privacy and security guidelines.